1st Faculty of Medicine Charles University 1st Faculty of Medicine Charles University Department of Nephrology
peiskerova 04.01.2010

History

      The Department of Nephrology is the youngest Department of Internal Medicine int the General Faculty Hospital (GFH), however the particular branch – Nephrology – has a very long tradition in GFH.  The Department of Nephrology of First Faculty of Medicine and General Faculty Hospital was established by the Minister of Health in June 2003, however it started its independent existence only in January 2004. This Department of Nephrology was created by splitting the original First Department of Internal Medicine into two separated units – First Department of Internal Medicine – specialized in Hemato-oncology and a new Department of Nephrology. This operation was a result of a specialization process of different Departments of Internal Medicine within the frame of GFH.

      However, nephrology has a long tradition in GFH and it may be noted that the roots of Czech Nephrology originate in this Hospital. Professor Jan Brod, the founder of Czech Nephrology started to work at the First Department of Internal Medicine in 1937 and the branch of Nephrology came into existence following his return from abroad, after the World War II.  At that time, only several clinical beds were reserved for nephrology patients, first clearance methods were elaborated and first attempts of glomerulonephritis treatment by cytostatic agents were effected. During his period in GFH Professor Brod published his first important monograph „Clinical physiology and pathology of kidneys“.  

      Following the departure of Professor Brod to the Research institute of blood circulation diseases, further development of Nephrology was linked with the names of Professor Otto Schück and Doctor Jarmila Stříbrná. Prof. Schück worked in GFH form 1951 to 1962 when he departed to the Research Institute of pharmacotherapy of Internal disease in Krč. In GFH he published several important studies, mostly about plasmatic and hepatic clearance and separated renal function. Doctor Stříbrná during her activity in GFH (1951 – 1964) worked mostly on the subject of water diuresis, concentration ability of the kidney and vesico-ureteral links.

     After 1950 Nephrology began to develop also in the Second Department of Internal Medicine of GFH. In 1955, thanks to Professor Vančura and Doctors Mirko Chytil and Severin Daum, the first artificial kidney of Alwall type was installed here, as a first one in former Czechoslovakia and the whole Middle and East Europe. Following the departure of Prof. Schück and Doctor Stříbrná, the development of Nephrology continued at the Second Department of Internal Medicine, thanks to Prof. Válek, Doctor Tomášek and Doctor Knotková.  

     In 1987, following the reconstruction of the First Department of Internal Medicine, a new Inpatient Nephrology Department was opened and the artificial kidney was transferred from the Second Department of Internal Medicine to the new ward. In 1999, a second Inpatient Nephrology Department was created, including a small Outpatient Nephrology Clinic and also Peritoneal dialysis program. In 2003, a new and larger Outpatient Nephrology Clinic was opened, located in Policlinic of the Faculty of Medicine on Square Charles.

     Department of Nephrology is mainly focused on diagnostics and treatment of glomerulonephritides, including systemic disease affecting the kidney (renal vasculitis, lupus nephritis), hereditary renal diseases and secondary hypertension. We provide and develop hemodialysis and other blood-purification methods, such as peritoneal dialysis, plasmapheresis and continual renal replacement therapies. Thanks to the Intensive Care Unit, we are able to care of critically ill nephrology patients. The Department provides undergraduate and postgraduate education in Internal Medicine and Nephrology.

      In the research field the Department cooperates with other institutes, such as

1)     Institute of biology and genetics and Institute of hereditary metabolic diseases, in the area of hereditary renal diseases (polycystic kidney disease, Fabry disease .. )

2)      First Department of Internal Medicine (renal complications of monoclonal gamapathies, bone marrow transplantation in primary amyloidosis), Second Department of Internal Medicine (cardiovascular complications of renal patients, Fabry disease)

3)      Third Department of Internal Medicine (diabetic nephropathy, venous access investigation)

4)      Institute of Clinical Biochemistry and Laboratory Diagnostics (oxidative stress in pathogenesis of  chronic nephropathies, prognostic factors in chronic nephropathies)

5)      Institute of microbiology and immunology (ANCA positive vasculitides)

6)      Institute of Rheumatology (ANCA positive vasculitides, lupus nephritis, secondary amyloidosis)

7)     First and Second Surgical Department, Urology Department, Radiology Department

      From the international point of view, our specialists are involved in activities of European Vasculitis Study Group, European Renal cDNA Bank and participate in various international clinical studies, focused mainly on new treatment of chronic glomerulopathies, renal insufficiency and cardiovascular complications of renal patients.

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